Important Safety Information

Last updated: October 2026

About Vyoni

Vyoni is a telehealth platform operated by Hydrohealth Solutions LLC. Vyoni connects patients with independently licensed healthcare providers who evaluate patients, make clinical decisions, and issue prescriptions when medically appropriate. Vyoni does not practice medicine, diagnose conditions, or prescribe medications. All medical decisions are made solely by independent licensed healthcare providers.

Completing the eligibility questionnaire on the Vyoni website does not create a doctor-patient relationship between the individual and Vyoni or Hydrohealth Solutions LLC. A doctor-patient relationship is established only between the individual and the prescribing licensed healthcare provider.

Compounded medications

Compounded medications are not FDA-approved. They are not reviewed by the FDA for safety, effectiveness, or quality. Compounded medications available through Vyoni are prepared by an FDA-registered 503A compounding pharmacy based on a licensed physician's prescription.

The decision to prescribe a compounded medication is made by the licensed healthcare provider based on clinical judgment informed by the patient's medical history and telehealth consultation. The prescribing provider retains full discretion over whether to prescribe.

Compounded estradiol & progesterone vaginal cream

Vyoni's platform facilitates access to compounded estradiol & progesterone vaginal cream for the treatment of genitourinary syndrome of menopause (GSM). The following safety information applies to estradiol-containing products generally. Patients should discuss their specific risks and benefits with their prescribing physician.

Contraindications

Estrogen therapy, including vaginal estrogen, may not be appropriate for individuals with:

• Known or suspected breast cancer, or a history of breast cancer
• Known or suspected estrogen-dependent neoplasia
• Undiagnosed abnormal genital bleeding
• Active deep vein thrombosis, pulmonary embolism, or a history of these conditions
• Active arterial thromboembolic disease (e.g., stroke, myocardial infarction)
• Known liver dysfunction or disease
• Known hypersensitivity to estradiol or any ingredient in the formulation
• Known or suspected pregnancy

Warnings and precautions

Estrogen-containing products carry warnings including but not limited to:

• Cardiovascular disorders: Estrogen therapy has been associated with an increased risk of stroke and deep vein thrombosis. Patients with risk factors for cardiovascular disease should discuss these risks with their provider.
• Malignant neoplasms: Estrogen use has been associated with an increased risk of endometrial cancer in women with a uterus who use unopposed estrogen. The risk of breast cancer may be increased with estrogen use. Patients should discuss their individual risk with their prescribing physician.
• Dementia: Estrogen therapy should not be used for the prevention of dementia.
• Gallbladder disease: Estrogen use has been associated with an increased risk of gallbladder disease requiring surgery.

Note: Low-dose vaginal estrogen is associated with minimal systemic absorption compared to oral or transdermal estrogen. Patients should discuss their individual risk profile with their prescribing provider.

Common side effects

Common side effects of vaginal estrogen & progesterone cream may include:

• Vaginal discharge
• Vaginal irritation or itching
• Headache
• Pelvic pain or cramping
• Breast tenderness

This is not a complete list of side effects. Contact your prescribing physician if you experience any concerning symptoms.

When to seek emergency medical attention

Seek immediate medical attention if you experience:

• Severe allergic reaction (difficulty breathing, swelling of the face or throat, hives)
• Signs of a blood clot (sudden severe headache, chest pain, shortness of breath, leg pain or swelling)
• Signs of a stroke (sudden numbness or weakness, confusion, vision changes, difficulty speaking)
• Unusual vaginal bleeding
• Severe abdominal pain

Vyoni is not an emergency medical service. If you are experiencing a medical emergency, call 911 or go to your nearest emergency room.

Results and outcomes

Individual results may vary. Treatment outcomes are not guaranteed. The effectiveness of compounded estradiol & progesterone vaginal cream depends on multiple factors including individual physiology, adherence to the prescribed treatment regimen, and the severity of symptoms. Some patients may not experience improvement.

All claims and information on this website regarding treatment outcomes are based on general medical literature about vaginal estrogen therapy. They do not constitute a guarantee of results for any individual patient.

Partner pharmacy

Prescriptions are fulfilled by Foothills Pharmacy, an FDA-registered compounding pharmacy located at 2727 W Baseline Rd #1, Tempe, AZ 85283. Phone: (480) 496-4444. All prescriptions are filled and shipped by licensed U.S. pharmacies in compliance with applicable state and federal law.

Medical provider partners

Medical consultations and prescribing services are provided by independently licensed healthcare providers in Vyoni's partner network. All providers are licensed in the states where they provide care. All consultations are conducted in compliance with applicable state and federal telehealth regulations.

States of service

Vyoni's telehealth services are available to patients located in all 50 U.S. states and the District of Columbia. All consultations are conducted by licensed U.S. healthcare providers, and all prescriptions are dispensed by licensed U.S. pharmacies. Treatment is only provided where clinically appropriate and permitted by applicable state and federal law.

Contact

If you have questions about the safety information on this page or about your treatment, contact your prescribing physician or reach out to us:

Hydrohealth Solutions LLC
8 The Green Suite D
Dover, DE 19901
contact@getvyoni.com